Preface to the Second Edition.Preface to the First Edition.1. Introduction.2. Some Basic Considerations Concerning Estimation in Clinical Trials.3. The AB/BA Design with Normal Data.4. Other Outcomes and the AB/BA Design.5. Normal Data from Designs with Three or More Treatments.6. Other Outcomes from Designs with Three or More Treatments.7. Some Special Designs.8. Graphical and Tabular Presentation of Cross-over Trials.9. Various Design Issues.10. Mathematical Approaches to Carry-over.References.Author Index.Subject Index.
Kurztext / Annotation
Cross-over trials are experiments in which subjects, whether patients or healthy volunteers, are each given a number of treatments with the object being to study the differences between these treatments. They are used extensively in clinical research, particularly in the early phases of drug development. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials.